Crohn's Disease Research Paper Example | Topics and Well Written Essays - 1000 words

Crohns Disease - Research newspaper ExampleConversely, Crohns distemper may appear at any part of the digestive tractfrom the let the cat out of the bag down to the anus, but most commonly at the lower part of the small intestine (ileum), involving mayhap all layers of the intestine, with normal healthy bowel between sections of disorderd bowel. (National Digestive Diseases Information Clearinghouse 1) Although the exact first of Crohns disease is still a mystery, the condition is associated with a problem in the reaction of the bodys immune placement called an autoimmune disorder, where the immune system is unable to distinguish between normal and foreign bodies. (Longstreth) According to Dr. Schoenfeld and Dr. Wu, the cells and proteins piece of music the immune system, normally defend the body against foreign invaders, such as harmful bacteria, viruses, fungi, etc. by being launched, causing inflammationan important defense mechanism of the system, within the tissues where activation occurs, and triggered only in the presence of harmful invaders furthermore, continued and abnormal activation of the immune system in the absence of the state foreign bodies results to chronic inflammation and ulceration. Whether this abnormality in the immune system response is a seduce or a consequence of Crohns disease is yet to be determined by scientists, but explore shows that a number of divisorsbrokertic inheritance, the immune system itself, and the environment, own to with the aforementioned inflammation in the digestive tract. (NDDIC 2) NDDIC (2) has affirmed that it was found out that people with Crohns disease have high levels of tumor necrosis factor (TNF), a protein produced by the immune system. Additionally, a gene called NOD2 has been recently identified as an important find factor of the bodys response to some bacteria, and mutations of which increases a persons susceptibility to the disease other genes essential in the understanding of the pathoge nesis of Crohns diseasesuch as autophagy related 16-like 1 gene (ATG 16L1) and IRGM, both having a role to play in macrophage defects, are continually being studied. (Schoenfeld & Wu) Incidentally, there have been studies showing higher levels of E. coli bacteria in the intestines of those suffering from Crohns diseaseprobably resulting from a genetically determined defect with intestinal mucosal macrophages in eliminating E. coli, as well as speculations that infection by certain bacteriasuch as strains of mycobacterium, causes the disease, but still no substantial evidence supporting(a) it, added Dr. Schoenfeld and Dr. Wu. Crohns disease may occur at any age, but more often at ages between 15 and 35 other risk factors include (1) family history of the disease, (2) Jewish ancestry, and (3) smoking. (Longstreth) Nevertheless, the exact family between the factors, possible causes and the disease, have not been proven and remains unknown, to date. According to Dr. Paul Klenerman, th e symptoms of Crohns disease vary depending on its severity and locationmany only have humble symptoms like periods of mild fever, at times, accompanied with blood in the stool and abdominal pain loss of appetite, unintentional slant loss, general malaise, and boils, may also appear.